prefrontal cortex

noun

: the gray matter of the anterior part of the frontal lobe that is highly developed in humans and plays a role in the regulation of complex cognitive, emotional, and behavioral functioning

Examples of prefrontal cortex in a Sentence

Recent Examples on the Web
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Practices like meditation or simply taking a moment to pause before switching tasks, help strengthen networks connected to the prefrontal cortex—the region that is notably involved in planning, inhibition and sustained attention. Lauryn Higgins, Flow Space, 27 May 2025 Even short-term sleep loss increases inflammatory markers, disrupts blood sugar regulation and impairs the prefrontal cortex, which governs decision-making and impulse control. Ximena Araya-Fischel, Forbes.com, 19 May 2025 Gilbert observed that brain activity in the part of the prefrontal cortex that normally reflects future plans was strongly reduced when an external reminder was used. Celia Ford, Vox, 10 Mar. 2025 Both exercise groups tended to show less loss of brain volume over 12 months, including in the prefrontal cortex, the part of the brain responsible for decision-making, personality, and executive function. Emily Kay Votruba, EverydayHealth.com, 25 Apr. 2025 See All Example Sentences for prefrontal cortex

Word History

First Known Use

1892, in the meaning defined above

Time Traveler
The first known use of prefrontal cortex was in 1892

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Cite this Entry

“Prefrontal cortex.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/prefrontal%20cortex. Accessed 4 Jun. 2025.

Medical Definition

prefrontal cortex

noun
: the gray matter of the anterior part of the frontal lobe that is highly developed in humans and plays a role in the regulation of complex cognitive, emotional, and behavioral functioning
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